Haoyu Niu

Proiect Support Oficer (Wellcome SangerInstitute, UK)

In 2019, he graduated from the Department of Chemistry at the University of Oxford with a PhD in Inorganic Chemistry, during which he conducted research on main group chemical catalysis and related computational chemistry. After my PhD, I changed my direction and engaged in data analysis and project management in Databiology, a bio-information startup company. Later, I joined the Treeof Life Programme of Wellcome Sanger Institute in 2021. He has led the AquaticSymbiosis Genomics Project to this day.

Topics:

Aquatic symbiosis: Genetic sequencing of 500 symbiotic systems

Professor Zhanjiang Liu, Vice President of Syracuse University, USA, gave a lecture entitled “An Exploration of the Sex Determination Mechanism of the spotted forktail”

Prof. Zhanjiang Liu gave a systematic presentation on the gender determination mechanism of the spotted furca Spotted furcauda  has XY sex determination The team identified the sex chromosome of spotted furca by QTL, and further bred all-male individuals by female nuclear development, conducted Y chromosome sequencing and assembly, found that the XY chromosome did not differentiate significantly, and identified about 8.6Mb of sex determination.

In combination with three-dimensional genome and epigenetic research methods, Professor Zhanjiang Liu’s team found that the methylation level of male and female spotted forbident appeared significantly and heritable on the sex chromosomes It was also found that hydin gene was specifically expressed in males, which may be a potential sex-determining gene. Treatment with methylation inhibitors resulted in sexual reversal, and a series of male genes such as hydin were upregulated.

In addition, temperature can also affect the sexual differentiation and methylation of the spotted pedicurd Through a series of works, Professor Zhanjiang Liu’s team proposed that the sex of the spotted voxur may be controlled by genome imprinting Finally, Professor Zhanjiang Liu shared his thoughts and prospects on the development of epigenetic research in fish, pointing out that methylation control of sex differentiation may be widespread in fish.

Professor Zhanjiang Liu, Vice President of Syracuse University, USA, gave a lecture entitled “An Exploration of the Sex Determination Mechanism of the spotted forktail”

Prof. Zhanjiang Liu gave a systematic presentation on the gender determination mechanism of the spotted furca Spotted furcauda  has XY sex determination The team identified the sex chromosome of spotted furca by QTL, and further bred all-male individuals by female nuclear development, conducted Y chromosome sequencing and assembly, found that the XY chromosome did not differentiate significantly, and identified about 8.6Mb of sex determination.

In combination with three-dimensional genome and epigenetic research methods, Professor Zhanjiang Liu’s team found that the methylation level of male and female spotted forbident appeared significantly and heritable on the sex chromosomes It was also found that hydin gene was specifically expressed in males, which may be a potential sex-determining gene. Treatment with methylation inhibitors resulted in sexual reversal, and a series of male genes such as hydin were upregulated.

In addition, temperature can also affect the sexual differentiation and methylation of the spotted pedicurd Through a series of works, Professor Zhanjiang Liu’s team proposed that the sex of the spotted voxur may be controlled by genome imprinting Finally, Professor Zhanjiang Liu shared his thoughts and prospects on the development of epigenetic research in fish, pointing out that methylation control of sex differentiation may be widespread in fish.